TruVue is a study that uses an internet-connected pill bottle to track and monitor adherence to a once-daily medication that can prevent HIV (called “pre-exposure prophylaxis” or “PrEP”) among particularly high-risk men who also struggle with alcohol and drug use. Although many well-conducted studies have shown that taking PrEP can prevent HIV, its effectiveness depends on how well those who are prescribed PrEP adhere to their regimen. Much of the initial clinical research on PrEP studied whether patients took the medication by asking them at their routine study visits, which provides a very broad picture of adherence. By using an internet-connected pill bottle, we can see how well patients take their medication on a day-to-day basis. In this study, we also collect minimally-intrusive online "diaries" of participants' drinking, drug use, and sexual behavior to see how these things intersect with medication adherence. We hope that our findings can be used to determine when these patients have problems taking their medication, so we can connect them with resources that will help them do so as recommended. 

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